Keene Vendelbo

Our HCV research program investigated novel 2′-dihalogenated nucleoside HCV polymerase inhibitors and identified compound 1, a 5′-phosphoramidate prodrug of 2′-deoxy-2′-α-bromo-β-chloro uridine. Although 1 had a favorable in vitro activity profile in HCV replicons, oral dosing in dog resulted in low levels of the active 5′-triphosphate (TP) in l…[Read more]

CONCLUSIONS This research first demonstrates that sensory nerve-deficient microenvironment impairs tooth haemostasis by inducing apoptosis of DPSCs via activin B/SMAD2/3 signalling. Our study provides the evidence for the crucial role of sensory nerve in tooth homeostasis. © 2020 The Authors. Cell Proliferation published by John Wiley & Sons…[Read more]

Lastly, we found a correlation between high FeNO levels at baseline and reduction in ACQ scores at 1 year. CONCLUSION We conclude that omalizumab shows effectiveness in severe allergic asthma in a real life setting, by reducing exacerbation rate, improving patient perspective outcomes and airway calibre, together with reducing type-2 airway…[Read more]

BACKGROUND The superficial temporal artery to middle cerebral artery (STA-MCA) end-to-side anastomosis is the most commonly used direct extracranial-to intracranial (EC-IC) bypasses type for Moyamoya disease (MMD). In progressive MMD without suitable scalp arteries other bypass constructs may need to be considered to augment blood flow. CASE…[Read more]